Thymalfasin

Overview of Thymalfasin Thymalfasin is a chemically synthesised version of thymosin alpha-1 (Tα1). It is identical to human thymosin alpha-1, found in the thymus gland. Thymosin hormone plays a vital role in immune system regulation. Researchers study lab-made Thymalfasin for its potential ability to modulate immune function in preclinical models. Chemical Properties PubChem CID 16130571 Chemical Structure Depiction Molecular Formula C129H215N33O55 Synonyms Thymalfasin 62304-98 Thymosin alpha Thymosin alpha 1 Zadaxin Molecular Weight 3108.3 g/mol CAS 69521-94-4 IUPAC N-acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-L-asparagine How Does Thymalfasin Work? Thymalfasin has been shown to work by modulating different immune signalling pathways in experimental models. These pathways particularly control how the body detects and responds to threats in experimental models. Thymalfasin appears to bind to Toll-like receptors (mainly TLR2 and TLR9) on dendritic cells and macrophages. This binding activates the MyD88–NF-κB pathway and increases the production of immune-stimulating cytokines known as interferon-α, IL-2, and IL-12. That whole process helps enhance antigen presentation through increased MHC class I and II expression. This allows immune cells to recognise viruses, bacteria, and abnormal cells more efficiently. Handling and Storage of Thymalfasin Handling and storing Thymalfasin is important for long-term research use. Here are the guidelines to follow: Researchers have suggested that Thymalfasin powder can be stored at -20°C. In solvent -80°C, for 6 months. Use it carefully in lab settings. Make sure to check the airport and customs regulations when considering travelling with Thymalfasin. Do not use Thymalfasin for research purposes after the expiration date shown on the packaging, as suggested by the FDA. Keep vials tightly sealed and clearly labelled with concentration and date of reconstitution. Use sterile containers to prevent contamination. Keep it away from moisture and humidity. Research Application of Thymalfasin Thymalfasin is being researched by various medical analysts in labs for its following potential applications. Researchers study Thymalfasin for its potential to enhance immune responses against viruses like Hepatitis B, C, and HIV in experimental models. Investigated as an adjunct to chemotherapy or immunotherapy to restore immune function in preclinical models research. The compound is being explored for boosting antiviral immunity (e.g., COVID-19) in experimental models. Disclaimer This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions . If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use Reference Links Dominari, A., Hathaway III, D., Pandav, K., Matos, W., Biswas, S., Reddy, G., Thevuthasan, S., Khan, M. A., Mathew, A., Makkar, S. S., Zaidi, M., Fahem, M. M. M., Beas, R., Castaneda, V., Paul, T., Halpern, J., & Baralt, D. (2020). Thymosin alpha 1: A comprehensive review of the literature. World Journal of Virology, 9(5), 67–78. https://doi.org/10.5501/wjv.v9.i5.67 (2025). Clinicaltrials.gov. https://www.clinicaltrials.gov/study/NCT06821100 Aynekulu Mersha, D. G., Fromme, S. E., van Boven, F., Arteaga-Henríquez, G., Wijkhuijs, A., van der Ent, M., Berghmans, R., Baune, B. T., Drexhage, H. A., & Dalm, V. (2025). Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression. Brain, Behavior, & Immunity – Health, 43, 100934. https://doi.org/10.1016/j.bbih.2024.100934