Syn-Ake

Overview of SYN-AKE Syn-Ake is a synthetic tripeptide mimc the activity of Waglerin-1, originally found in the venom of Temple Viper. It is being investigated in cosmetic and biochemical studies for its interaction with neuromuscular signaling pathways. Pubchem CID 71465152 Structure 2D 3D Molecular Formula C 23 H 37 N 5 O 7 Peptide Class Synthetic tripeptide analog IUPAC beta-alanyl-L-prolyl-3-aminomethyl-L-alanine benzylamide acetic acid Molecular Weight 495.6 g/mol Purity ≥99% (HPLC verified) Appearance White to off-white lyophilized powder Storage Conditions Store at -20°C in a dry, sealed container Stability Stable under recommended laboratory storage conditions Synonyms 823202-99-9 Syn-ake UNII-38H206R00R 38H206R00R CAS 823202-99-9 Certificate of Analysis Available HPLC Testing Verified FDA status Not FDA approved Solubility information DMSO: 10 mM, Sonication is recommended. Solubility Soluble in sterile water or appropriate research solvents How Does Syn-Ake Work? Researchers have found that Syn-Ake does not work by paralysing muscle contraction. Instead, it may interact with receptor-mediated signaling pathways in laboratory models. In research preclinical studies, Syn-Ake has been shown to work by binding to nicotinic acetylcholine receptors (nAChRs). This interaction may modulate acetylcholine-mediated signaling in experimental systems. Acetylcholine signaling is responsible for triggering muscle contraction. However, the mechanism has not been clinically validated in humans. Handling Instructions of Syn-Ake in Laboratory Research Intended Use Strictly for laboratory research purposes only Reconstitution Perform under sterile lab conditions using appropriate solvent Handling Precautions Avoid moisture, light exposure, and repeated freeze-thaw cycles Safety Classification Not for human or animal consumption Research Application of Syn-Ake Syn-Ake is being studied by researchers in laboratory and cosmetic science settings for its following potential applications. Syn-Ake is investigated in cosmetic research models examining peptide interactions with neuromuscular signaling relevant to skin appearance. A few researchers explore Syn-Ake’s effects on neuromuscular signaling and acetylcholine-mediated pathways in research models. Evaluating cosmetic anti-aging formulations in research laboratory models. Why Purchase Research-Grade Syn-Ake from Purerawz? Purerawz supplies research-grade Syn-Ake accompanied by analytical testing documentation intended solely for laboratory research purposes. We offer first- and third-party tested Syn-Ake with a proper Certificate of Analysis . In addition, we have a hassle-free shipping process and easy, secure transaction options. Disclaimer This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions . If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co   ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use Reference Links Bahar Gok, Yasemin Budama-Kilinc, & Serda Kecel-Gunduz. (2023). Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests. Journal of Biomolecular Structure and Dynamics, 42(2), 1-15. https://doi.org/10.1080/07391102.2023.2223681 Andrada Pintea, Manea, A., Cezara Pintea, Vlad, R.-A., Birsan, M., Antonoaea, P., Emoke Margit Redai, & Ciurba, A. (2025). Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review. Biomolecules, 15(1), 88-88. https://doi.org/10.3390/biom15010088 Moisa, D. G., Anca Maria Juncan, Rus, L.-L., Andreea Loredana Vonica-Tincu, Cormos, G., & Gligor, F. G. (2025). Viper Venom and Synthetic Peptides: Emerging Active Ingredients in Anti-Ageing Cosmeceuticals. Applied Sciences, 15(8), 4501-4501. https://doi.org/10.3390/app15084501