Orexin A

Orexin A for Sale | Purerawz Wakefulness and Sleep Research Neuropeptide

What is Orexin A?

Orexin A, also known as Hypocretin-1, is a 33-amino-acid neuropeptide produced by specialized neurons located in the lateral hypothalamus, perifornical area, and dorsomedial hypothalamus. First independently identified in 1998 by two separate research groups, Sakurai and colleagues discovered it as a ligand for orphan G-protein-coupled receptors while de Lecea and colleagues identified it as a hypothalamus-specific transcript encoding prepro-hypocretin. Its distinct molecular structure includes an N-terminal pyroglutamyl residue, two intrachain disulfide bonds, and C-terminal amidation.

Researchers study Orexin A extensively for its possible role in regulating wakefulness, arousal, appetite, and energy balance in experimental models. All products on Purerawzus.com are strictly intended for laboratory and research use only and are not approved by the FDA for human or veterinary use.

Orexin A Chemical Properties

Property	Details
Product Name	Orexin A
Synonyms	Orexin-A, Orexine A, Hypocretin-1, 8RDY08V4VC
CAS Number	205599-75-3
PubChem CID	56842143
Molecular Formula	C152H243N47O44S4
Molecular Weight	3561.1 g/mol
Structure Features	N-terminal pyroglutamyl residue, two intrachain disulfide bonds, C-terminal amidation
Storage	-20°C, dry desiccated, protected from light
Research Use	Laboratory and Scientific Research Only
Regulatory Status	Not approved by the FDA for human or veterinary use

How Does Orexin A Work?

Scientific investigation suggests that Orexin A may function by binding to two specific receptors in research models, OX1R and OX2R, both of which play key roles in wakefulness and arousal regulation. Upon binding to these receptors Orexin A may trigger several downstream biological effects in experimental settings:

Potential Mechanism	Research Context
OX1R and OX2R Receptor Binding	May bind to orexin receptors to activate downstream wakefulness signaling pathways
Calcium Signaling Activation	Receptor binding may increase calcium signaling in neurons in preclinical models
Wake-Promoting Neuron Excitation	May excite neurons in dopamine, norepinephrine, and serotonin wakefulness pathways
Sustained Wakefulness Support	Believed to help maintain stable wakefulness and mental focus in preclinical models
Sleep Disorder Research	Deficiency in Orexin signaling has been linked to narcolepsy in laboratory studies

Potential Benefits of Orexin A in Research

Early stage scientific investigation has identified several areas where Orexin A may offer significant value in preclinical and experimental research settings:

Potential Benefit	Research Context
Wakefulness Research	Studied for its possible role in maintaining stable wakefulness in preclinical models
Narcolepsy Research	Being explored for its potential applications in studying narcolepsy symptoms in lab settings
Sleep Deprivation Research	Investigated for its possible role in counteracting sleep deprivation effects in research models
Appetite Regulation Research	Early studies suggest possible influence on appetite and feeding behavior in preclinical models
Energy Balance Research	Being studied for its possible role in regulating energy homeostasis in experimental settings
Cognitive Research	Being explored in age-related cognitive decline studies in laboratory environments
Arousal Research	Studied for its possible influence on arousal and alertness mechanisms in research models

Please note: All benefits listed are based on early stage preclinical research. This peptide is strictly intended for research purposes and is not approved for human or veterinary use.

Potential Research Areas of Orexin A

Research Area	Potential Focus
Sleep and Wakefulness Research	Studying how Orexin A regulates wakefulness and arousal through OX1R and OX2R activation
Narcolepsy Research	Investigating its possible applications in studying narcolepsy and sleep disorder mechanisms
Sleep Deprivation Research	Exploring its possible role in counteracting sleep deprivation effects in preclinical models
Appetite and Feeding Research	Studying its possible influence on appetite regulation and feeding behavior in lab models
Energy Homeostasis Research	Investigating its possible role in regulating energy balance in experimental settings
Cognitive Decline Research	Exploring its possible applications in age-related cognitive decline research
Dopamine Pathway Research	Studying its possible interactions with dopamine signaling and reward pathways
Cardiovascular Research	Investigating its possible influence on autonomic nervous system and blood pressure regulation
Stress and Anxiety Research	Exploring its possible role in stress response and anxiety regulation in research models
Neurodegenerative Research	Studying possible links between Orexin A deficiency and neurodegenerative conditions

Handling and Storage of Orexin A

Proper handling and storage of Orexin A are essential for maintaining compound integrity throughout research use:

Condition	Recommendation
Primary Storage	Store at -20°C, dry desiccated, and protected from light
Chemical Separation	Store away from oxidizing agents at all times
Solution Storage	Freeze in small single-use aliquots to prevent repeated freeze-thaw cycles
Handling Environment	Handle in a well-ventilated laboratory area at all times
Skin and Eye Protection	Avoid all contact with skin, eyes, and clothing during handling
Inhalation Prevention	Do not breathe dust, fumes, gas, mist, vapors, or spray
Vial Management	Keep vials tightly sealed and clearly labelled with concentration and reconstitution date
Container Standards	Use sterile containers at all times to prevent contamination
Moisture Control	Keep away from moisture and humidity throughout storage
Expiration Compliance	Do not use after the expiration date shown on packaging

Why Buy Orexin A from Purerawzus.com?

Purerawzus.com is your trusted source for research-grade Orexin A. Every product is first and third-party tested and comes with a full Certificate of Analysis confirming identity, purity, and concentration. Our convenient shipping process and multiple secure payment options make your ordering experience seamless and straightforward. Visit our how to pay page for a complete step by step guide to all available payment methods and checkout instructions.

Feature	Details
Testing	First and independent third-party lab tested
Documentation	Certificate of Analysis (COA) included with every order
Shipping	Free international shipping on orders over $100
Payment Options	Multiple secure payment methods available
Support	24/7 expert customer support

Frequently Asked Questions

Is Orexin A Safe for Human Consumption?

No. The FDA has not approved Orexin A for human or veterinary use. Purerawzus.com supplies this compound strictly for laboratory and scientific research purposes only.

What Side Effects Have Been Observed With Orexin A?

As Orexin A remains under active scientific investigation its complete side effect profile has not yet been fully established. Researchers are encouraged to follow all applicable laboratory safety protocols when handling this compound. Further studies are required to confirm its full safety profile.

How Should Orexin A be Stored?

Store Orexin A at -20°C in a dry desiccated environment protected from light and away from oxidizing agents. For solution storage freeze in small single-use aliquots to avoid repeated freeze-thaw cycles. Keep vials tightly sealed, clearly labelled, and stored in sterile containers away from moisture and humidity.

Is Orexin A Legal for Research Use?

Orexin A is legal for laboratory and research use in applicable regions. The FDA has not approved it for human or veterinary applications. All research must comply with applicable institutional standards and local regulatory guidelines.

Disclaimer

All information on this page is provided for educational purposes only and does not constitute medical or professional advice. Products are for laboratory and research use only. By ordering you agree to our Terms and Conditions. Contact us at sales@purerawzus.com for any concerns.

All products are for laboratory and research purposes only and are not intended for veterinary or human use.

References

Sun, N., Wei, R., Jia, B., Lou, T., Li, Z., Nie, X., Yu, W., Zhao, M., & Li, Q. (2024). Bibliometric analysis of orexin: A promising neuropeptide. Medicine, 103(43), e40213. https://doi.org/10.1097/md.0000000000040213

Xia, L., Liu, H. Y., Wang, B. Y., Lin, H. N., Wang, M. C., & Ren, J.-X. (2023). A review of physiological functions of orexin: From instinctive responses to subjective cognition. Medicine, 102(26), e34206. 

https://doi.org/10.1097/MD.0000000000034206

Heinicke, U., Talbot, S. R., Filippos Thanasis, Adam, E. H., Knethen, A. von, Steinbicker, A. U., Zinn, S., Zacharowski, K., & Flinspach, A. N. (2025). Systemic role of orexin A, substance P, bradykinin, and DABK in severe COVID-19 and 2.5-yr follow-ups: an observational study. BJA Open, 14, 100415. 

https://doi.org/10.1016/j.bjao.2025.100415