Ibutamoren (MK-677)

Overview of MK-677 (Ibutamoren) Ibutamoren (MK-677) is an investigational small-molecule compound. A few preliminary studies have indicated that MK-677 functions as a growth hormone secretagogue. Research indicates that MK-677 increases GH and IGF-1 levels, which are biologically associated with muscle and bone metabolism; however, clinical outcomes remain inconclusive. MK-677 has been investigated in both preclinical models and controlled human clinical trials, but it is not FDA-approved for medical use. How Does MK-677 (Ibutamoren) Work? MK-677 has been shown to work by mimicking the action of endogenous ghrelin in experimental models. Researchers believe that MK-677’s working action involves selective agonism of the ghrelin receptor (GHSR-1a). The activation of this receptor may stimulate the hypothalamus and pituitary to increase the secretion of growth hormone (GH) in experimental models. Increased GH levels subsequently raise circulating insulin-like growth factor 1 (IGF-1). Pubchem CID 178024 Molecular Formula C 27 H 36 N 4 O 5 S Synonyms Ibutamoren 159634-47-6 ibutamoreno GJ0EGN38UL L 163191 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide L-163,191 DTXSID90166700 2-AMINO-N-((R)-2-(BENZYLOXY)-1-((1-(METHYLSULFONYL)SPIRO(INDOLINE-3,4′-PIPERIDIN)-1′-YL)CARBONYL)ETHYL)-2-METHYLPROPIONAMIDE MK-677 Molecular Weight 528.7 g/mol IUPAC 2-amino-2-methyl- N -[(2 R )-1-(1-methylsulfonylspiro[2 H -indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide Chemical Structure Description 2D 3D CAS 159634-47-6 Hazards Hazards Comprehensive hazard classification under GHS has not been fully established. Handle using standard laboratory safety precautions. General Information Do not eat, drink, or smoke when using this product for research purposes If skin contact Wash thoroughly after handling Eye contact Rinse Eyes Purity >98% SOLUBILITY DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ ml; PBS (pH 7.2): 10 mg/ml Availability Available in liquid and powder form for research purposes. FDA Status Not approved for human consumption. Handling and Storage of Ibutamoren (MK-677) Handling and storing Ibutamoren (MK-677) is important for long-term research use. Here are the guidelines to follow: Researchers have suggested that Ibutamoren (MK-677) can be stored at 2-8°C in lyophilized powder form. For long-term storage, -20°C (frozen) is recommended. However, it is better to always store the product according to the package instructions. In solution, store aliquoted at -20ºC for up to one month or at – 80°C for up to six months . Use it carefully in lab settings. Keep vials tightly sealed and clearly labeled with concentration and date of reconstitution. Research Application of Ibutamoren (MK-677) Ibutamoren (MK-677) is being researched by various medical researchers in labs for its following potential applications. May have been investigated for its potential to increase growth Hormone and IGF-1 levels in research models. Researchers use this compound to study GH- and IGF-1–mediated pathways associated with protein metabolism in experimental models. A few analysts believe that Ibutamoren (MK-677) may have the potential to improve bone density and mineralization in long-term experimental studies. Where Ibutamoren (MK-677) can be purchased online? Purerawz supplies Ibutamoren (MK-677) intended for laboratory research use and sources materials from manufacturers that provide batch documentation and certificates of analysis. Disclaimer This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions . If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co . ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use Reference Links Murphy, M. G., Plunkett, L. M., Gertz, B. J., He, W., Wittreich, J., Polvino, W. M., & Clemmons, D. R. (1998). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. The Journal of Clinical Endocrinology and Metabolism, 83(2), 320–325. https://doi.org/10.1210/jcem.83.2.4551 Lee, J., Kwon, A., Chae, H. W., Lee, W. J., Kim, T. H., & Kim, H. S. (2018). Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei Medical Journal, 59(10), 1174–1180. https://doi.org/10.3349/ymj.2018.59.10.1174 Smith, R. G., & Thorner, M. O. (2023). Growth Hormone Secretagogues as Potential Therapeutic Agents to Restore Growth Hormone Secretion in Older Subjects to Those Observed in Young Adults. The Journals of Gerontology: Series A, 78(Supplement_1), 38–43. https://doi.org/10.1093/gerona/glad022