FOXO4-DRI (Proxofim)

FOXO4-DRI (Proxofim) for Sale | Purerawz Senolytic Research Peptide

What is FOXO4-DRI (Proxofim)?

FOXO4-DRI, also known by its research name Proxofim, is a synthetically engineered D-retroinverso peptide specifically designed to study the removal of senescent cells, commonly referred to as aged or damaged cells that have stopped dividing but continue to persist within tissues. These senescent cells are believed to contribute to age-related dysfunction and tissue deterioration over time. By targeting the interaction between the FOXO4 protein and the tumor suppressor protein p53, FOXO4-DRI has become a compound of significant interest in aging, longevity, and cellular health research. Purerawzus.com offers FOXO4-DRI  peptides exclusively for laboratory and scientific research use only and it is not intended for human or veterinary use.

FOXO4-DRI Chemical Properties

Property	Details
Chemical Name	FOXO4-DRI
CAS Number	2460055-10-9
Synonyms	Proxofim, Forkhead Box Protein O4, AFX, AFX1
Molecular Formula	C228H388N86O64
Molecular Weight	5358.05 g/mol
Peptide Sequence	H-Pyr-Glu-Leu-Arg-Ala-Leu-Asn-Ser-Ser-OH
Appearance	Solid
Color	White to Off-White
Research Use	Laboratory and Scientific Research Only
Regulatory Status	Not approved by the FDA for human or veterinary use

How Does FOXO4-DRI Work?

The mechanism of FOXO4-DRI centers on disrupting a specific protein interaction within senescent cells. Under normal biological conditions, the FOXO4 protein binds to p53, a critical tumor suppressor protein, inside senescent cells. This binding keeps damaged or aged cells alive despite their non-functional state, preventing the natural process of apoptosis, or programmed cell death, from occurring.

FOXO4-DRI is engineered to interfere with this FOXO4-p53 binding interaction. By blocking this connection, p53 is released and becomes free to initiate apoptotic signaling within the senescent cell. This allows researchers to study how aged and dysfunctional cells may be selectively cleared from tissue, providing a valuable model for exploring the relationship between cellular senescence and healthy aging.

Potential Benefits of FOXO4-DRI in Research

Early stage scientific investigation has highlighted several promising areas where FOXO4-DRI may offer value in preclinical and experimental research settings:

Potential Benefit	Research Context
Senescent Cell Clearance	May support the selective removal of senescent cells in preclinical research models
Tissue Repair Support	Early findings suggest it could improve tissue repair by clearing dysfunctional cells
Healthy Aging Research	Studied for its potential to promote healthier cellular aging in laboratory settings
Neuroprotection Research	Some studies suggest it may help protect brain cells from age-related decline
Muscle Strength and Endurance	Researchers are investigating its possible link to improved strength and endurance in lab models
Vascular Health Research	May help reduce cellular stress in blood vessel tissue in experimental models
Longevity Research	Being explored as a model compound for studying mechanisms of longevity and age-related dysfunction

Please note: All benefits listed are based on early stage preclinical research using animal or cell models. How this compound functions in humans remains unknown and its safety and effects have not been proven.

Potential Research Areas of FOXO4-DRI

Research Area	Potential Focus
Senolytic Research	Studying its potential to selectively clear senescent cells in preclinical models
Anti-Aging Research	Exploring its possible role in promoting healthier tissue aging and cellular function
Apoptosis Research	Investigating how FOXO4-DRI influences programmed cell death pathways in research models
p53 Pathway Research	Studying the interaction between FOXO4 and p53 and how blocking it affects cell survival
Neuroprotection Research	Examining its possible role in protecting brain cells from age-related deterioration
Muscle Research	Investigating its potential link to muscle strength and endurance in experimental models
Vascular Health Research	Exploring its possible effects on cellular stress reduction in blood vessel tissues
Cancer Research	Studying how senescent cell clearance may relate to cancer biology and tumor microenvironments
Longevity Research	Examining how selective senescent cell removal may contribute to healthier aging models

FOXO4 vs FOXO4-DRI

Understanding the distinction between FOXO4 and FOXO4-DRI is essential for researchers working with this compound:

Feature	FOXO4	FOXO4-DRI (Proxofim)
Type	Naturally occurring protein	Synthetic D-retroinverso peptide
Function	Binds p53 to keep senescent cells alive	Blocks FOXO4-p53 binding to trigger apoptosis
Origin	Endogenous biological protein	Laboratory engineered research compound
Research Application	Studied as a target protein	Used as a research tool to study senescent cell clearance

Current State of FOXO4-DRI Research

Research on FOXO4-DRI remains in the early preclinical phase. Most available studies have been conducted using animal models and cell-based experiments. Current findings suggest that FOXO4-DRI may support senescent cell clearance, improve tissue repair, offer neuroprotective effects, and potentially influence muscle and vascular health in research models. Researchers studying anti-aging, longevity, and cellular health consider FOXO4-DRI a valuable model compound for exploring the biology of senescence. However all findings require further validation and the compound’s effects and safety in humans remain unestablished.

Where to Buy FOXO4-DRI (Proxofim) Online

Pure raws is your trusted source to buy high-purity FOXO4-DRI for scientific research. Every purchase comes fully documented and independently verified so you can conduct your research with complete confidence. We offer multiple secure payment options to make your ordering experience as smooth as possible. Visit our how to pay page for a full breakdown of available payment methods and step by step instructions.

Feature	Details
Testing	Independent third-party lab tested
Documentation	Certificate of Analysis (COA) included with every order
Shipping	Free international shipping on orders over $100
Payment Options	Multiple secure payment methods available
Support	24/7 expert customer support

Frequently Asked Questions

What does FOXO4-DRI peptide do in research?

In laboratory studies FOXO4-DRI may block the interaction between FOXO4 and p53 within senescent cells, potentially allowing these aged or damaged cells to be selectively cleared through apoptosis.

What is the difference between FOXO4 and FOXO4-DRI?

FOXO4 is a naturally occurring protein that binds to p53 to keep senescent cells alive. FOXO4-DRI is a synthetic peptide specifically engineered to block this binding and trigger programmed cell death in senescent cells.

What is the FOXO4-DRI peptide sequence?

The peptide sequence of FOXO4-DRI is: H-Pyr-Glu-Leu-Arg-Ala-Leu-Asn-Ser-Ser-OH.

Is FOXO4-DRI approved for human use?

No. The FDA has not approved FOXO4-DRI for human or veterinary use. Purerawzus.com supplies this compound strictly for laboratory and research purposes only.

Disclaimer

All information on this page is provided strictly for educational purposes and does not represent medical or professional advice of any kind. Every product available through Purerawzus.com is designated solely for laboratory and scientific research use. Clinical studies must be conducted under appropriate Institutional Review Board oversight while preclinical work must comply with IACUC guidelines in accordance with the Animal Welfare Act. Customers are strongly encouraged to independently verify all information prior to completing a purchase. By placing your order you confirm your agreement with our Terms and Conditions. For any product concerns or questions please contact us directly at sales@purerawzus.com.

Purerawzus.com sells all products for laboratory and research purposes only and does not intend them for veterinary or human use.