Deslorelin

Deslorelin – Product Information Deslorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). It is used to manage artificial insemination in horses, regulate reproduction in dogs, and manage adrenal disease in ferrets. Deslorelin is also used to induce ovulation in mares and cattle. In humans, deslorelin has undergone extensive testing as a potential treatment for children with precocious puberty and also for the treatment of prostate cancer. Deslorelin is currently undergoing trials for the treatment of fibroids, endometriosis, and menorrhagia. PureRawz sells Deslorelin for laboratory and research use only. Deslorelin CAS Number 57773-65-6 Molar Mass 1282.475 g/mol Chemical Formula C64H83N17O12 IUPAC Name (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide What is Deslorelin? Deslorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). The GnRH controls the release of luteinizing hormone (LSH) and follicle-stimulating hormone (FSH). Both hormones stimulate the testes in males and ovaries in females to produce sex hormones. [ R ][ R ] Like other synthetic GnRH analogs, deslorelin also stimulates the release of pituitary gonadotropins (LH and FSH). However, it’s different from other synthetic GnRH analogs in one critical way. That is that deslorelin is reportedly 100 times more potent than GnRH. [ R ][ R ] Deslorelin has been approved by the US FDA for inducing ovulation in cyclic estrous mares and managing adrenal gland disease in ferrets. In the EU, deslorelin treatment is used in healthy, sexually mature male dogs and male ferrets to make them temporarily infertile. [ R ][ R ] This synthetic gonadotropin-releasing hormone is available under many brand names, including SucroMate Equine, Superlorin F, Superlorin 12, and Superlorin-6. At the time of writing, deslorelin hasn’t been approved for any clinical use by any regulatory authority. How does Deslorelin Work? Deslorelin acts like the natural hormone GnRH to control the secretion of hormones involved in fertility. In dogs and ferrets, a continuously low dose of deslorelin has been shown to suppress the production of LH and FSH and, by extension, sperm, to make the animals temporarily infertile. [ R ] Deslorelin Research Following here is a summary of the existing research on deslorelin. The information given in this section is for educational purposes only. It doesn’t constitute medical advice. Speak to a qualified medical professional to know more about deslorelin acetate. Deslorelin and Infertility In healthy males, deslorelin treatment (50 µg or higher doses) for up to 10 weeks reportedly caused decreased or loss of fertility. These effects were shown to be reversible. All injection site swelling resolved within days of administration. [ R ] A preclinical study investigated the contraceptive effects of implants containing deslorelin in female mice. Fertility was successfully inhibited for 428 – 602 days post-treatment. The duration of contraception ranged from 344 to 761 days following the implant’s administration. [ R ] In male and female cats, sustained-release formulation deslorelin implants have been shown to generate effective, safe, and reversible long-term contraception. In pubertal cats, a 4.7 mg deslorelin implant suppressed steroid sex hormones for at least 15 months. [ R ] Deslorelin and Precocious Puberty Precocious puberty often leads to short adult height. A clinical study was conducted to investigate whether deslorelin treatment normalized the adult height of children with precocious puberty. The study involved 161 children with this condition. [ R ] Results from the study show that deslorelin treatment improved the adult height of the patients but didn’t fully restore the height to the patient’s genetic potential. The researchers hypothesize that better results could be obtained by administering deslorelin at a younger bone age. [ R ] Deslorelin and Prostate Cancer A cell-based study investigated whether deslorelin could improve the potency of docetaxel, a drug used to enhance the survival of prostate cancer patients. [ R ] Final results indicated that the deslorelin-docetaxel therapy had enhanced anti-proliferative, anti-tumor, and apoptotic efficacy by several folds in prostate cancer therapy. The combined drug also retained the pharmacologic effects of both docetaxel and deslorelin. [ R ] Deslorelin and Endometriosis Endometriosis is a painful condition in which tissue similar to the womb’s lining grows in other places, such as fallopian tubes and ovaries. It can affect women of any age. [ R ] In a clinical study, women with pelvic pain and confirmed endometriosis were treated with a six-month course of daily intranasal deslorelin with a concurrent administration of either transdermal estradiol, intranasal estradiol, or intranasal estradiol + testosterone. [ R ] The most significant reduction in the severity of endometriosis symptoms and signs occurred in the daily intranasal deslorelin with low-dose estradiol + testosterone treatment group. No injection site swelling was reported, and incidences of hot flashes were reportedly minimal. [ R ] Deslorelin and Uterine Fibroids Uterine fibroids are non-cancerous growths that develop in or around the womb. A clinical study reported that deslorelin treatment effectively reduces pain, bleeding, and uterine volume in women with symptomatic uterine fibroids. Notably, the improvements occurred without any changes to bone mineral density. [ R ] Where to Buy Deslorelin Online? PureRawz is the best place to buy the highest-quality Deslorelin online. In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. Note: PureRawz has expanded its Peptide (Unconstituted) category with new high-quality formulations such as the PTD-DBM, Bronchogen and several other innovative compounds. Summary Deslorelin is a synthetic analog of GnRH. Its intramuscular injection is reportedly capable of inducing ovulation within 48 hours of treatment in cyclic estrous mares with an ovarian follicle 30 to 40mm in diameter. Deslorelin has also been shown to cause temporary infertility in multiple animals. PureRawz sells Deslorelin for scientific, laboratory, and research purposes only. Disclaimer This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA). Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon. By completing and paying for your order, you agree to our Terms and Conditions . Customer satisfaction is our number one priority – if you are not 100% satisfied with the product you received, please contact us at support@purerawz.co ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.