Mazdutide

Overview of Mazdutide Mazdutide is also known by the name IBI-362. It is a synthetic dual-receptor agonist that appears to activate the GLP-1 (glucagon-like peptide-1) and GCCR (glucagon receptor) pathways in research models. Researchers investigate Mazdutide for its potential effects on weight loss, glucose control, and metabolic function regulation in experimental models. Mazdutide is an acylated peptide analogue with structural modifications designed to increase stability and prolong its half-life in research models. How Does Mazdutide Work? Mazdutide, a dual-receptor peptide agonist, works by activating two primary receptors: GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Researchers suggest that when these two receptors are activated, they carry out the following processes in experimental models. GLP-1R activation may slow gastric emptying and reduce appetite. It may also help enhance glucose-dependent insulin secretion, which supports controlling blood sugar and food intake. GCGR activation has been shown to increase energy expenditure and promote fat metabolism in preclinical models. This contributes to weight loss and improved metabolic efficiency in experimental models. Pubchem CID 167312357 Molecular Formula C 207 H 317 N 45 O 65 Synonyms Mazdutide IBI362 2259884-03-0 GTPL13924 IBI-362 Molecular Mass 4476 g/mol IUPAC 20-[[(1 S )-4-[2-[2-[2-[2-[2-[2-[[(5 S )-5-[[(2 S )-2-[[(2 S )-6-amino-2-[[(2 S )-6-amino-2-[[(2 S )-2-[[(2 S )-2-[[(2 S )-2-[[(2 S )-2-[[(2 S )-6-amino-2-[[(2 S )-2-[[(2 S )-2-[[(2 S )-2-[[(2 S )-2-[[(2 S ,3 R )-2-[[(2 S )-2-[[(2 S ,3 R )-2-[[2-[[(2 S )-5-amino-2-[[2-[[(2 S )-2-amino-3-(1 H -imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[(2 S )-1-[[2-[[2-[(2 S )-2-[[(2 S )-1-[(2-amino-2-oxoethyl)amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1 H -indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid Chemical Structure Description CAS 2259884-03-0 Hazards No dangerous hazards reported General information No special measures required After inhalation Supply fresh air; consult a doctor in case of complaints. After skin contact Generally, the product does not irritate the skin After eye contact Rinse opened eye for several minutes under running water After swallowing If symptoms persist, consult a doctor. Most important symptoms and effects, both acute and delayed. No further relevant information available. Purity >95% SOLUBILITY PBS (pH 7.2) Sparingly soluble: 1-10 mg/ml Potential Side Effects May cause diarrhea and gastrointestinal problems, as studied in research models Handling and Storage of Mazdutide Handling and storing the Mazdutide is important for long-term research use. Here are the guidelines to follow: Researchers have suggested that Mazdutide powder can be stored at -80°C for 2 years (long-term) and -20°C for 1 year (short-term) In solvent -80 ° C, 6 months Always reseal the vials promptly to avoid moisture. Do not expose to a humid environment Use carefully in lab settings Wear proper gloves and eyewear when dealing with this peptide Make sure to check the airport and customs regulations when considering travelling with Mazdutide Do not use Mazdutide for research purposes after the expiration date shown on the packaging. Research Application of Mazdutide Mazdutide is being researched by various medical researchers in labs for the following potential applications. Mazdutide is researched for its weight reduction and appetite control effects in experimental models. The peptide is also being studied for improving glucose regulation and insulin sensitivity in type 2 diabetes studies in preclinical models. Mazdutide is investigated for its potential to enhance energy expenditure and fat metabolism in laboratory non-human models. The compound may also be examined for cardiometabolic benefits, including improved lipid profiles and liver fat reduction in a few research models. Is Purerawz a Good Place to Buy Mazdutide Online? Purerawz is one of the best places to buy Mazdutide online due to its positive reputation. Out of various online shops , we stand out for our product quality and pricing. We source all our research chemicals from authorized and reputable manufacturers. We make sure that you do not have to go through any inconvenience. Therefore, we offer first- and third-party tested Mazdutide with a proper Certificate of Analysi s. In addition, we have a hassle-free shipping process and easy and secure transactions. Disclaimer This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions . If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co   ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.   Reference Links Dong, W., Bai, J., Yuan, Q., Zhang, Y., Zhang, Y., Zhang, Z., Yang, M., Li, H., Zhao, Z., & Jiang, H. (2025). Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysis. EBioMedicine, 117, 105791. https://doi.org/10.1016/j.ebiom.2025.105791 Bhattachar, S. N., Tham, L. S., Li, Y., Chua, L., Ng, S. X., Tang, Y., Ibriga, H., Ni, W., Sirel Gurbuz, Mather, K. J., & Thomas, M. K. (2025). Mazdutide reduces body weight in adults with overweight or obesity: A high dose Phase 1 trial. Diabetes, Obesity, and Metabolism. https://doi.org/10.1111/dom.70040