FGL

Overview of FGL Peptide FGL (Fibroblast Growth Factor-Like peptide) is a short synthetic peptide consisting of 15 amino acids. It is derived from a basic fibroblast growth factor, which is also known as the functional region of Fibroblast Growth Factor-2 (FGF-2). FGF-2 protein occurs naturally in the human body. This protein is believed to be associated with the family of proteins called growth factors (FGFs). FGFs help cells in various tissues communicate and work effectively. Researchers have suggested that FGL is not a full part of the FGF-2 protein. Rather, it is a small amino acid fragment that corresponds to a defined domain of FGF-2 that usually connects with cell receptors. FGL is being explored by various medical experts in laboratory settings for its potential to influence synaptic plasticity. A few researchers may also investigate the peptide to learn how neural cells communicate and form connections in research models. Additionally, researchers study FGL in the field of cognitive and behavioral studies in preclinical models. Chemical Properties Pubchem CID 16200289 Molecular Formula C 71 H 116 N 20 O 25 Synonyms FGL peptide 499993-62-3 HY-P3281 DA-53184 CS-0655069 Molecular Weight 1649.8 g/mol IUPAC L-alpha-glutamyl-L-valyl-L-tyrosyl-L-valyl-L-valyl-L-alanyl-L-alpha-glutamyl-L-asparagyl-L-glutaminyl-L-glutaminyl-glycyl-L-lysyl-L-seryl-L-lysyl-L-alanine Chemical Structure Description 2D Purity >95 % purity SOLUBILITY Insufficient solubility Potential Side Effects Nausea and dizziness were reported in research models Property Hygroscopic FDA Status Not approved for human use How Does FGL Peptide Work? In different preclinical models, FGL has appeared to work by mimicking the FG loop region of the Neural Cell Adhesion Molecule (NCAM). By using that same loop region, FGL may interact with the fibroblast growth factor receptor-1 (FGFR1) on the surface of nerve cells. Researchers believe that NCAM normally binds to FGFR1 during brain development and neural repair in humans. The synthetic FGL is a copy of the exact NCAM region that makes this contact. Researchers have learnt that FGL can bind to and activate FGFR1 in the same way NCAM does in experimental models. When FGL binds to FGFR1 in experimental models, it mainly triggers the following pathways: MAPK/ERK pathway PI3K–Akt pathway PLCγ pathway Once these pathways are activated, they may regulate neuronal survival and growth in preclinical models. In addition to that, they may help with neuronal differentiation, synapse formation, and plasticity in research models. Handling and Storage of FGL Handling and storing FGL is important for long-term research use. Here are the guidelines to handle FGL in lab settings: Researchers have suggested that FGL powder can be stored at -80°C for long-term and -20°C for short-term storage. Use it carefully in lab settings. Make sure to check the airport and customs regulations when considering travelling with FGL. Do not use FGL for research purposes after the expiration date shown on the packaging, as suggested by the FDA. Keep vials tightly sealed and clearly labeled with concentration and date of reconstitution. Use sterile containers to prevent contamination. Keep it away from moisture and humidity. Research Application of FGL FGL is being researched by various medical analysts in labs for its following potential applications. FGL is an interesting compound widely studied by researchers for its ability in neuronal communication and synaptic plasticity. A few medical experts investigate FGL for its potential role in enhancing learning and memory in preclinical models. Researchers study this compound in the field of Neurodegeneration. Why Buy FGL Online from Purerawz? Purerawz is one of the most reliable and authentic online shops that gives researchers of all levels the optimum quality FGL. FGL is available in capsule, nasal spray, and powder form. You can choose any form depending on your research goals. Each form is available in different quantities. We make sure that you do not have to go through any inconvenience. Therefore, we offer first- and third-party tested FGL with a proper Certificate of Analysi s. In addition, we have a hassle-free shipping process and easy, secure transaction options. Disclaimer This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions . If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use Reference Links Zellinger, C., Salvamoser, J. D., Seeger, N., Russmann, V., & Heidrun Potschka. (2014). Impact of the Neural Cell Adhesion Molecule-Derived Peptide FGL on Seizure Progression and Cellular Alterations in the Mouse Kindling Model. ACS Chemical Neuroscience, 5(3), 185–193. https://doi.org/10.1021/cn400153g Zhang, Z., Zheng, Q., Wu, Y., & Liu, Y. (2009). Biocompatibility of FGL peptide self-assembly nanofibers with neural stem cells in vitro. Journal of Wuhan University of Technology-Mater Sci Ed, 24(6), 992–996. https://doi.org/10.1007/s11595-009-6992-2 Johanne Louise Neiiendam, Køhler, L. B., Christensen, C. H., Li, S., Martin Wæver Pedersen, Dorte Kornerup Ditlevsen, M. Kornum, Kiselyov, V. V., Berezin, V., & Bock, E. (2004). An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. 91(4), 920–935. https://doi.org/10.1111/j.1471-4159.2004.02779.x